|
KMID : 0928520060160020309
|
|
Korean Journal of Lipidology
2006 Volume.16 No. 2 p.309 ~ p.316
|
|
|
Association of ACE Gene Polymorphism with Dyslipidemia in Elderly Korean Women
|
|
Song Min-Jun
Yu Sung-Hoon
Kim Hun-Sung
Chang You-Jin
Kim Yoon-Yi
Shin Hyun-Ho
|
|
|
Abstract
|
|
|
Objective: There have been various reports on how Angiotensin-Converting-Enzyme (ACE) gene is associated with the increased risk of cardiovascular diseases. In this study, we investigated the degree of connection between the ACE gene polymorphism and selected risk factors that are significant to atherosclerosis.
Methods: We determined ACE genotypes via Polymerase Chain Reaction (PCR) assays on 77 elderly Korean females (age≥55) who were not taking any antihypertensive, lipid lowering or antidiabetic agents, and measured their body-mass index, blood pressure, lipids and fasting blood sugar (FBS). Using these measures, the degree of each factor’s correlations with the different genotypes was analyzed.
Results: LDL cholesterol level in 13 DD subjects was measured significantly higher than that in 28 II subjects (128±38 mg/dL vs. 106±24 mg/dL, P=0.01), and it was also higher than the level in 36 ID subjects (116±23 mg/dL) although the difference with 36 ID subjects was not as significant as with 28 II. HDL cholesterol level tended to show lower level in DD types compared to II types (48±14 mg/dL vs. 55±16 mg/dL). No associations between ACE gene and body-mass index, blood pressure and FBS were detected.
Conclusion: The association of ACE polymorphism with cardiovascular diseases may be mediated, at least partially, through dyslipidema in elderly Korean women.
|
|
|
KEYWORD
|
|
|
Angiotensin-converting enzyme, Insertion/Deletion polymorphism, Dyslipidemia, Atherosclerosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|